A functional model of some Parkinson's Disease symptoms using a Guided Propagation Network
Identifieur interne : 001523 ( Istex/Checkpoint ); précédent : 001522; suivant : 001524A functional model of some Parkinson's Disease symptoms using a Guided Propagation Network
Auteurs : Claire Toffano-Nioche [France] ; Dominique Beroule [France] ; Jean-Pol Tassin [France]Source :
- Artificial Intelligence In Medicine [ 0933-3657 ] ; 1998.
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Abstract
This paper presents a computational model of Parkinson's Disease (PD) symptoms. Based on psychophysiological data, the underlying system (Guided Propagation Network) implements coincidence detection between internal flows and stimuli, and can be dynamically controlled for representing the action of neuromodulators such as dopamine (DA). By modelling the DA deficit involved in PD through a decrease of response thresholds in the production modules of a GPN, four symptoms are observed in experiments carried out on a computer simulation, and then attributed to a lack of synchrony between ‘proprioceptive stimuli’ and internal flows: reduced intensity, increased rate, saccades and spontaneous repetitions.
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DOI: 10.1016/S0933-3657(98)00036-0
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Based on psychophysiological data, the underlying system (Guided Propagation Network) implements coincidence detection between internal flows and stimuli, and can be dynamically controlled for representing the action of neuromodulators such as dopamine (DA). By modelling the DA deficit involved in PD through a decrease of response thresholds in the production modules of a GPN, four symptoms are observed in experiments carried out on a computer simulation, and then attributed to a lack of synchrony between ‘proprioceptive stimuli’ and internal flows: reduced intensity, increased rate, saccades and spontaneous repetitions.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Toffano Nioche, Claire" sort="Toffano Nioche, Claire" uniqKey="Toffano Nioche C" first="Claire" last="Toffano-Nioche">Claire Toffano-Nioche</name></noRegion><name sortKey="Beroule, Dominique" sort="Beroule, Dominique" uniqKey="Beroule D" first="Dominique" last="Beroule">Dominique Beroule</name><name sortKey="Tassin, Jean Pol" sort="Tassin, Jean Pol" uniqKey="Tassin J" first="Jean-Pol" last="Tassin">Jean-Pol Tassin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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